Dr Stephen Payne is an Associate Professor in in Biomedical Engineering at the Institute of Biomedical Engineering, part of the Department of Engineering Science (and winner of a Queen’s Anniversary Prize for Higher and Further Education in 2015) at the University of Oxford. His work lies primarily in mathematical modelling and signal processing related to cerebral blood flow and metabolism with the main focus on cerebral autoregulation. He has raised funding of over £1.2M in grants as a PI and been a Co-Investigator on 3 other grants (with a share of £1.3M), with funding coming from EPSRC, BBSRC, Wellcome Trust and the European Commission. His publications include 3 books (including ‘Cerebral Autoregulation’ in 2016 and ‘Cerebral Blood Flow and Metabolism’ in 2017), and 90 papers in international journals (h-index of 21 with over 1300 citations). He has supervised 23 DPhil students to successful completion. He is currently the Chair of CARNet and the Chair of the Organising Committee for both the 8th International Conference on Cerebral Autoregulation (June 2018) and the Royal Society meeting on Integrated Control of Cerebral Blood Flow (December 2018).

Charles Majoie is Professor of neuroradiology and interventional neuroradiologist in the Amsterdam UMC, location AMC, Amsterdam, The Netherlands. He is as a research leader and co-research leader involved in multiple national and international research collaborations in the field diagnosis and treatment of acute stroke. He was 1 of the 2 research leaders of the ground breaking MRCLEAN trial, that demonstrated a clear improvement in clinical outcome of patients with acute ischemic stroke after endovascular treatment. This changed the practice how patients with severe strokes are now treated worldwide. He is co research leader of the ongoing CONTRAST (MRCLEAN-2) trials aiming at treating more patients even more effectively and member of the executive committee of the HERMES Consortium: international collaboration of PIs of 7 randomized clinical trials in the field of endovascular treatment He is founder of the Neurovascular Intervention Center Amsterdam, a multidisciplinary center of excellence, combining patient care, research and education in the field of neurovascular diseases. He is  Principal Investigator of the AMC Research Institute and has supervised 25 PhD students and currently supervises another 14. He is Chairman of the Dutch Society of Neuroradiology.


He currently (Oct. 2018) has (co)authored more than 330 peer-reviewed manuscripts and has a Hirsch index of 42 (Web of Science).


Victor Azizi


A scientific programmer working at the UvA who likes to work on any complex software problem which is scientific in nature. In the INSIST project he is working on the workflow software which will bring together all the separate modules to create an in-silico trial.

Keywords: HPC programming, parallel code engineering and optimization




Is a graduate of Pharmacy of Montpellier University, PharmD, (term of 6-year University program), France, 1995. Then, she completed a degree in pharmacology of cardiovascular disease (one-year graduate degree required before doctoral studies) at Universities of Paris (Prof. Safar), and Lyon (Prof. Sassard), 1996. She started a Doctoral Thesis about “Sudden cardiac death and heart failure” in a model of coronary embolizations in dog (INSERM U390 Cardiovascular Physiology, Pr Vassor and Pr Davy Montpellier). In 2003, she started to work for Servier Laboratories where she was in charge of developing pharmacological studies in stroke prevention to support the clinical development of an anti-platelet agent.  She also has experience in chronic venous disease and ulcer pathologies. Since 2014, she is a clinical and translational research leader working in different projects in cardiovascular area. In addition, she is involved in IMI and H2020 projects.

                  Heleen van Beusekom

Dr. H.M.M. Heleen van Beusekom, PhD, FESC. Experimental Pathobiologist; Team leader for Experimental vascular interventions and vascular repair. Head Histology & MS Imaging Lab at Experimental Cardiology, Erasmus MC University Medical Center.

Brief summary of research over the last five years. My work focusses on micro- and macro-vascular injury and repair in cardiovascular disease. Thrombosis is essential in initiating myocardial infarction, acute ischemic stroke atherosclerosis, and plays an important role in vascular healing. Recently it was discovered that NETs, neutrophil extracellular DNA traps with toxic properties, play an important role in thrombus formation and subsequently also in myocardial infarction and stroke. We are building the MRCLEAN and CONTRAST national biobanks for acute ischemic stroke, and the local CorTAsk biobank containing peri-procedural plasma and thrombus aspirates retrieved during routine treatment for STEMI.

Professional memberships and output. Dr. van Beusekom is a Fellow of the European Society of Cardiology since 2012, and member of the working groups “Atherosclerosis and Vascular Biology” and  “Thrombosis” and the “Stroke Council”. She is also a member of the “International Working group on Intracoronary OCT” the “Dutch Pathology Society”, the “Dutch society of Mass Spectrometry” and the “Mass spectrometry Imaging Society”. She is an editorial board member of “Eurointervention” and Section editor for basic science and experimental cardiology for “Cardiology Journal”.  Scopus ID: 7004104745. Google Scholar: H-factor 37

This email address is being protected from spambots. You need JavaScript enabled to view it.


Raymond Padmos

Earned a bachelor's degree in Nanobiology (cum laude) in 2015, followed by a master's degree in Nanobiology in 2017, at TU Delft and Erasmus University Rotterdam (joint degree).

In 2018, he started as a PhD Student at the University of Amsterdam (UvA). His work involves computational modelling of cerebral blood flow with coupling to perfusion with the aim of predicting infarct volume after stroke. 

In addition, he is also working on integrating different models made within INSIST to set up In Silico clinical trials.   


Keywords: blood flow modelling, stroke, mathematical modelling


Max van der Kolk
Scientific programmer
Computational Science Lab, University of Amsterdam

After graduating in mechanical engineering in 2015, I started my PhD research in the Structural Optimisation and Mechanics group at Delft University of Technology. My research aims to apply topology optimisation, a form of structural design optimisation, to the automated design of high-precision optical instruments. This design process is driven by large-scale gradient-based optimisation combined with computational mechanics to find material distributions to optimise a design's performance. During this work, I greatly enjoyed combining numerical modelling with mathematical programming and developing their numerical implementations, bringing me to my current position as scientific programmer at the Computational Science Lab, University of Amsterdam. Nowadays, I focus on developing numerical models with various applications in the field of computational biomedicine. Outside work, I like to go bouldering and tinker with software.

numerical modelling; mathematical programming